Synthesis of mannich bases of methyl ester of 2,3-indolo-betulinic acid
Authors
Petrova Anastasiya Valer’evna
Ufa Institute of Chemistry, Ufa Federal Research Center of RAS
Akhmetkirieva Vilena Rifovna
Ufa University of Science and Technology
Kukovinets Olga Sergeevna
Ufa University of Science and Technology
Abstract
The reaction of methyl ester of 2,3-indolobetulinic acid with propargyl bromide in the presence of NaH yielded a derivative containing a terminal triple bond in the indole ring. Subsequent aminomethylation using paraformaldehyde and a secondary amine in the presence of a monovalent copper (CuI) catalyst led to new Mannich bases of interest as potential pharmacologically significant compounds.
DOI: 10.33184/bulletin-bsu-2025.4.9
Author Biographies
Petrova Anastasiya Valer’evna, Ufa Institute of Chemistry, Ufa Federal Research Center of RAS
Candidate of Chemical Sciences, researcher of Ufa Institute of Chemistry,Ufa Federal Research Center of RAS, ORCID: 0000-0003-2910-6805Researcher ID: ABC-9578-2021 Scopus ID: 57196985570
Akhmetkirieva Vilena Rifovna, Ufa University of Science and Technology
Master’s student
Kukovinets Olga Sergeevna, Ufa University of Science and Technology
Doctor of Chemical Sciences, Professor of the Department of Technical Chemistry and Materials Science of Ufa University of Science and Technology ORCID ID 0000-0003-3047-9502
