Hybrid organic materials for modeling the biocompatibility of metal implants

Abstract

High biocompatibility of metal implants can be achieved by creating the organic layers that should have a high affinity to the metal surface, be non-toxic, prevent the adsorption of non-specific proteins, and also contain various ligands that improve adhesion, proliferation, and differentiation of cells, exhibit anti-inflammatory and antimicrobial properties. Modern trends in the development of such coatings imply the design of relatively complex multifunctional structures. The report represents the results on the synthesis of bisphosphonic acid derivatives, including natural polysaccharides and RGD-oligopeptide. The compounds were applied for the Ti surface modified by plasma electrolytic oxidation (PEO). In vitro studies of cell adhesion and proliferation showed that this approach is promising for effective modeling of the biological properties of the surface of metal implants.